CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt O60674
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O60674
JAK2_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK2

PDB Structure

PDB 4AQC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-A]Pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of Cep-33779.
Dugan, B.J., Gingrich, D.E., Mesaros, E.F., Milkiewicz, K.L., Curry, M.A., Zulli, A.L., Dobrzanski, P., Serdikoff, C., Jan, M., Angeles, T.S., Albom, M.S., Mason, J.L., Aimone, L.D., Meyer, S.L., Huang, Z., Wells-Knecht, K.J., Ator, M.A., Ruggeri, B.A., Dorsey, B.D.
J.Med.Chem.