CATH Classification

Domain Context

CATH Clusters

Superfamily Molybdopterin biosynthesis MoaE subunit
Functional Family Molybdopterin synthase catalytic subunit

Enzyme Information

2.8.1.12
Molybdopterin synthase.
based on mapping to UniProt O96007
Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H(2)O = molybdopterin + 2 [molybdopterin- synthase sulfur-carrier protein].
-!- Catalyzes the synthesis of molybdopterin from cyclic pyranopterin phosphate. -!- Two sulfur atoms are transferred to cyclic pyranopterin phosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor. -!- Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur- carrier proteins) that are thiocarboxylated at the C-terminus by EC 2.8.1.11, molybdopterin synthase sulfurtransferase. -!- The reaction occurs in prokaryotes and eukaryotes.

UniProtKB Entries (1)

O96007
MOC2B_HUMAN
Homo sapiens
Molybdopterin synthase catalytic subunit

PDB Structure

PDB 4AP8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Molybdopterin Synthase Catalytic Subunit (Mocs2B)
Vollmar, M., Kiyani, W., Krojer, T., Goubin, S., Allerston, C., Froese, D.S., von Delft, F., Burgess-Brown, N., Bountra, C., Arrowsmith, C.H., Edwards, A., Yue, W.W.
To be Published