CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.11350
Functional Family GDP-fucose protein O-fucosyltransferase 2

Enzyme Information

2.4.1.221
Peptide-O-fucosyltransferase.
based on mapping to UniProt Q9Y2G5
Transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor.
-!- Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. -!- The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.

UniProtKB Entries (1)

Q9Y2G5
OFUT2_HUMAN
Homo sapiens
GDP-fucose protein O-fucosyltransferase 2

PDB Structure

PDB 4AP6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Human Pofut2: Insights Into Thrombospondin Type 1 Repeat Fold and O-Fucosylation.
Chen, C.I., Keusch, J.J., Klein, D., Hess, D., Hofsteenge, J., Gut, H.
Embo J.