CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | Disintegrin and metalloproteinase domain-containing protein 22 |
Enzyme Information
| 3.4.24.46 |
Adamalysin.
based on mapping to UniProt P34179
Cleavage of 1-Phe-|-Val-2, 5-His-|-Leu-6, 14-Ala-|-Leu-15, 15-Leu-|-Tyr- 16, and 16-Tyr-|-Leu-17 of insulin B chain.
-!- From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). -!- Two isoenzymes of approximately 24 kDa that inactivate alpha-1- proteinase inhibitor by a single cleavage. -!- Belongs to peptidase family M12B.
|
UniProtKB Entries (1)
| P34179 |
VM12_CROAD
Crotalus adamanteus
Snake venom metalloproteinase adamalysin-2
|
PDB Structure
| PDB | 4AIG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
2 angstrom X-ray structure of adamalysin II complexed with a peptide phosphonate inhibitor adopting a retro-binding mode.
FEBS Lett.
|