CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family cyclin-dependent kinase-like 1 isoform X1

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q00532
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q00532
CDKL1_HUMAN
Homo sapiens
Cyclin-dependent kinase-like 1

PDB Structure

PDB 4AGU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Human Cdkl1 Kinase Domain
Canning, P., Sharpe, T.D., Allerston, C., Savitsky, P., Pike, A.C.W., Muniz, J.R.C., Chaikuad, A., Kuo, K., Burgess-Brown, N., Ayinampudi, V., Zhang, Y., Thangaratnarajah, C., Ugochukwu, E., Vollmar, M., Krojer, T., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Knapp, S., Bullock, A.
To be Published