CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P17612
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P17612
KAPCA_HUMAN
Homo sapiens
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 4AE6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Function of the Human Sperm-Specific Isoform of Protein Kinase a (Pka) Catalytic Subunit Calpha2
Hereng, T.H., Backe, P.H., Kahmann, J., Scheich, C., Bjoras, M., Skalhegg, B.S., Rosendal, K.R.
J.Struct.Biol.