CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Cathepsin E

Enzyme Information

3.4.23.4
Chymosin.
based on mapping to UniProt P00794
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single 104-Ser-Phe-|-Met-Ala-107 bond in kappa-chain of casein.
-!- Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. -!- Found among mammals with postnatal uptake of immunoglobins. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.3.

UniProtKB Entries (1)

P00794
CHYM_BOVIN
Bos taurus
Chymosin

PDB Structure

PDB 4AA8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Camel and Bovine Chymosin: The Relationship between Their Structures and Cheese-Making Properties.
Langholm Jensen, J., Molgaard, A., Navarro Poulsen, J.C., Harboe, M.K., Simonsen, J.B., Lorentzen, A.M., Hjerno, K., van den Brink, J.M., Qvist, K.B., Larsen, S.
Acta Crystallogr.,Sect.D