1 keywords

CATH Domain 4a73A02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.110 L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
Homologous Superfamily 3.90.110.10 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q5SJA1
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q5SJA1
LDH_THET8
Thermus thermophilus HB8
L-lactate dehydrogenase

PDB Structure

PDB 4A73
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Sampling the Conformational Energy Landscape of a Hyperthermophilic Protein by Engineering Key Substitutions
Colletier, J.P., Aleksandrov, A., Coquelle, N., Mraihi, S., De Mendoza-Barbera, E., Field, M., Madern, D.
Mol.Biol.Evol.