CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tryptase gamma 1

Enzyme Information

3.4.21.59
Tryptase.
based on mapping to UniProt Q15661
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

Q15661
TRYB1_HUMAN
Homo sapiens
Tryptase alpha/beta-1

PDB Structure

PDB 4A6L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Library Design and the Discovery of a Potent and Selective Mast Cell Beta-Tryptase Inhibitor as an Oral Therapeutic Agent.
Liang, G., Aldous, S., Merriman, G., Levell, J., Pribish, J., Cairns, J., Chen, X., Maignan, S., Mathieu, M., Tsay, J., Sides, K., Rebello, S., Whitely, B., Morize, I., Pauls, H.W.
Bioorg.Med.Chem.Lett.