CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Acetylserotonin O-methyltransferase

Enzyme Information

2.1.1.4
Acetylserotonin O-methyltransferase.
based on mapping to UniProt P46597
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
-!- Some other hydroxyindoles also act as acceptor, more slowly.

UniProtKB Entries (1)

P46597
ASMT_HUMAN
Homo sapiens
Acetylserotonin O-methyltransferase

PDB Structure

PDB 4A6E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.
Botros, H.G., Legrand, P., Pagan, C., Bondet, V., Weber, P., Ben-Abdallah, M., Lemiere, N., Huguet, G., Bellalou, J., Maronde, E., Beguin, P., Haouz, A., Shepard, W., Bourgeron, T.
J.Pineal Res.