CATH Classification

Domain Context

CATH Clusters

Superfamily C2 domain
Functional Family Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P42337
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt P42337
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

UniProtKB Entries (2)

P42337
PK3CA_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
P27986
P85A_HUMAN
Homo sapiens
Phosphatidylinositol 3-kinase regulatory subunit alpha

PDB Structure

PDB 4A55
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Regulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases.
Hon, W.-C., Berndt, A., Williams, R.L.
Oncogene