CATH Classification

Domain Context

CATH Clusters

Superfamily DUSP-like
Functional Family ubiquitin carboxyl-terminal hydrolase 15 isoform X1

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q9Y4E8
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q9Y4E8
UBP15_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 15

PDB Structure

PDB 4A3P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Variability of the Ubiquitin Specific Protease Dusp-Ubl Double Domains.
Elliott, P.R., Liu, H., Pastok, M.W., Grossmann, G.J., Rigden, D.J., Clague, M.J., Urbe, S., Barsukov, I.L.
FEBS Lett.