CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase

Enzyme Information

6.3.3.3
Dethiobiotin synthase.
based on mapping to UniProt B0F481
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin.
-!- CTP has half the activity of ATP.
2.6.1.62
Adenosylmethionine--8-amino-7-oxononanoate transaminase.
based on mapping to UniProt B0F481
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4- methylthio-2-oxobutanoate + 7,8-diaminononanoate.
-!- S-adenosylhomocysteine can also act as donor.

UniProtKB Entries (1)

B0F481
BIODA_ARATH
Arabidopsis thaliana
Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial

PDB Structure

PDB 4A0R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biochemical and Structural Characterization of the Arabidopsis Bifunctional Enzyme Dethiobiotin Synthetase-Diaminopelargonic Acid Aminotransferase: Evidence for Substrate Channeling in Biotin Synthesis.
Cobessi, D., Dumas, R., Pautre, V., Meinguet, C., Ferrer, J.L., Alban, C.
Plant Cell