CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family inactive tyrosine-protein kinase transmembrane receptor ROR1

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q01974
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q01974
ROR2_HUMAN
Homo sapiens
Tyrosine-protein kinase transmembrane receptor ROR2

PDB Structure

PDB 3ZZW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Kinase Domain of Ror2
Tresaugues, L., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Edwards, A.M., Ekblad, T., Graslund, S., Karlberg, T., Nyman, T., Schuler, H., Thorsell, A.G., Weigelt, J., Nordlund, P.
To be Published