CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Mitogen-activated protein kinase 1

Enzyme Information

2.7.11.24
Mitogen-activated protein kinase.
based on mapping to UniProt P63086
ATP + a protein = ADP + a phosphoprotein.
-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P63086
MK01_RAT
Rattus norvegicus
Mitogen-activated protein kinase 1

PDB Structure

PDB 3ZU7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries.
Kummer, L., Parizek, P., Rube, P., Millgramm, B., Prinz, A., Mittl, P.R., Kaufholz, M., Zimmermann, B., Herberg, F.W., Pluckthun, A.
Proc.Natl.Acad.Sci.USA