CATH Domain 3zrhA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.560

Domain Context

CATH Clusters

Superfamily	1.25.40.560
Functional Family	ubiquitin thioesterase ZRANB1 isoform X1

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt Q9UGI0

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q9UGI0

ZRAN1_HUMAN

Homo sapiens

Ubiquitin thioesterase ZRANB1

PDB Structure

PDB	3ZRH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An Ankyrin-Repeat Ubiquitin-Binding Domain Determines Trabid'S Specificity for Atypical Ubiquitin Chains. Licchesi, J.D.F., Mieszczanek, J., Mevissen, T.E.T., Rutherford, T.J., Akutsu, M., Virdee, S., Oualid, F.E., Chin, J.W., Ovaa, H., Bienz, M., Komander, D. Nat.Struct.Mol.Biol.