CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Beta-lactamase

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P9WKD3
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P9WKD3
BLAC_MYCTU
Mycobacterium tuberculosis H37Rv
Beta-lactamase

PDB Structure

PDB 3ZHH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Directed Evolution of Mycobacterium Tuberculosis Beta-Lactamase Reveals Gatekeeper Residue that Regulates Antibiotic Resistance and Catalytic Efficiency.
Feiler, C., Fisher, A.C., Boock, J.T., Marrichi, M.J., Wright, L., Schmidpeter, P.A.M., Blankenfeldt, W., Pavelka, M., Delisa, M.P.
Plos One