CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family tRNA N6-adenosine threonylcarbamoyltransferase

Enzyme Information

2.3.1.234
N(6)-L-threonylcarbamoyladenine synthase.
based on mapping to UniProt E8XBD7
L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L- threonylcarbamoyladenine(37) in tRNA.
-!- The enzyme is involved in the synthesis of N(6)- threonylcarbamoyladenosine(37) in tRNAs, which is found in tRNAs with the anticodon NNU, i.e. tRNA(Ile), tRNA(Thr), tRNA(Asn), tRNA(Lys), tRNA(Ser) and tRNA(Arg). -!- Formerly EC 2.6.99.4.

UniProtKB Entries (1)

E8X8J1
E8X8J1_SALT4
Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74
Putative M22 peptidase yeaZ

PDB Structure

PDB 3ZET
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Dimer of Two Essential Salmonella Typhimurium Proteins, Ygjd & Yeaz and Calorimetric Evidence for the Formation of a Ternary Ygjd-Yeaz-Yjee Complex.
Nichols, C.E., Lamb, H.K., Thompson, P., Omari, K.E., Lockyer, M., Charles, I., Hawkins, A.R., Stammers, D.K.
Protein Sci.