CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family cyclin-dependent kinase-like 1 isoform X1

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt Q8IVW4
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q8IVW4
CDKL3_HUMAN
Homo sapiens
Cyclin-dependent kinase-like 3

PDB Structure

PDB 3ZDU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Human Cdkl3 Kinase Domain
Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Pike, A.C.W., Quigley, A., MacKenzie, A., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
To be Published