CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08922
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08922
ROS1_HUMAN
Homo sapiens
Proto-oncogene tyrosine-protein kinase ROS

PDB Structure

PDB 3ZBF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Acquired Resistance to Crizotinib from a Mutation in Cd74-Ros1
Awad, M.M., Katayama, R., Mctigue, M., Liu, W., Deng, Y., Brooun, A., Friboulet, L., Huang, D., Falk, M.D., Timofeevski, S., Wilner, K.D., Lockerman, E.L., Khan, T.M., Mahmood, S., Gainor, J.F., Digumarthy, S.R., Stone, J.R., Mino-Kenudson, M., Christensen, J.G., Iafrate, J., Engelman, J.A., Shaw, A.T.
N.Engl.J.Med.