CATH Classification

Domain Context

CATH Clusters

Superfamily Adenosylhomocysteinase-like
Functional Family Adenosylhomocysteinase

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt O51933
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

O51933
SAHH_THEMA
Thermotoga maritima MSB8
Adenosylhomocysteinase

PDB Structure

PDB 3X2F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima
Zheng, Y., Chen, C.C., Ko, T.P., Xiao, X., Yang, Y., Huang, C.H., Qian, G., Shao, W., Guo, R.T.
J.Struct.Biol.