CATH Classification

Domain Context

CATH Clusters

Superfamily 1.50.10.10
Functional Family Unsaturated chondroitin disaccharide hydrolase

Enzyme Information

3.2.1.180
Unsaturated chondroitin disaccharide hydrolase.
based on mapping to UniProt Q8E372
Beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc6S + H(2)O = 5-dehydro- 4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate.
-!- The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. -!- It prefers the sulfated disaccharides to the unsulfated disaccharides.

UniProtKB Entries (1)

Q8E372
UCDH_STRA3
Streptococcus agalactiae NEM316
Unsaturated chondroitin disaccharide hydrolase

PDB Structure

PDB 3WUX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of unsaturated glucuronyl hydrolase mutant D115N/K370S from Streptococcus agalactiae
Nakamichi, Y., Oiki, S., Mikami, B., Murata, K., Hashimoto, W.
to be published