CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Squalene synthase

Enzyme Information

2.5.1.21
Squalene synthase.
based on mapping to UniProt P37268
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
-!- This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols. -!- In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. -!- When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP). -!- High concentrations of FPP inhibit the production of squalene but not of PSPP.

UniProtKB Entries (1)

P37268
FDFT_HUMAN
Homo sapiens
Squalene synthase

PDB Structure

PDB 3WSA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
Shang, N., Li, Q., Huang, C.H., Oldfield, E., Guo, R.T.
To be Published