CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family Uracil-DNA glycosylase

Enzyme Information

3.2.2.27
Uracil-DNA glycosylase.
based on mapping to UniProt Q6GJ88
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.

UniProtKB Entries (1)

Q6GJ88
UNG_STAAR
Staphylococcus aureus subsp. aureus MRSA252
Uracil-DNA glycosylase

PDB Structure

PDB 3WDF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor.
Wang, H.C., Hsu, K.C., Yang, J.M., Wu, M.L., Ko, T.P., Lin, S.R., Wang, A.H.J.
Nucleic Acids Res.