CATH Domain 3wciE00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.600	Farnesyl Diphosphate Synthase
	1.10.600.10	Farnesyl Diphosphate Synthase

Domain Context

CATH Clusters

Superfamily	Farnesyl Diphosphate Synthase
Functional Family	Squalene synthase

Enzyme Information

2.5.1.21

Squalene synthase.

based on mapping to UniProt P37268

2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).

-!- This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols. -!- In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. -!- When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP). -!- High concentrations of FPP inhibit the production of squalene but not of PSPP.

UniProtKB Entries (1)

P37268

FDFT_HUMAN

Homo sapiens

Squalene synthase

PDB Structure

PDB	3WCI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Squalene synthase as a target for Chagas disease therapeutics. Shang, N., Li, Q., Ko, T.P., Chan, H.C., Li, J., Zheng, Y., Huang, C.H., Ren, F., Chen, C.C., Zhu, Z., Galizzi, M., Li, Z.H., Rodrigues-Poveda, C.A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T.M., de Souza, W., Urbina, J.A., Wang, A.H., Docampo, R., Li, K., Liu, Y.L., Oldfield, E., Guo, R.T. Plos Pathog.