CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Squalene synthase

Enzyme Information
Squalene synthase.
based on mapping to UniProt P37268
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
-!- This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols. -!- In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. -!- When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP). -!- High concentrations of FPP inhibit the production of squalene but not of PSPP.

UniProtKB Entries (1)

Homo sapiens
Squalene synthase

PDB Structure

External Links
Primary Citation
Squalene synthase as a target for Chagas disease therapeutics.
Shang, N., Li, Q., Ko, T.P., Chan, H.C., Li, J., Zheng, Y., Huang, C.H., Ren, F., Chen, C.C., Zhu, Z., Galizzi, M., Li, Z.H., Rodrigues-Poveda, C.A., Gonzalez-Pacanowska, D., Veiga-Santos, P., de Carvalho, T.M., de Souza, W., Urbina, J.A., Wang, A.H., Docampo, R., Li, K., Liu, Y.L., Oldfield, E., Guo, R.T.
Plos Pathog.