CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydroorotate Dehydrogenase A, chain A, domain 2
Functional Family Dihydroorotate dehydrogenase (fumarate)

Enzyme Information

1.3.98.1
Dihydroorotate oxidase (fumarate).
based on mapping to UniProt Q4D3W2
(S)-dihydroorotate + fumarate = orotate + succinate.
-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.

UniProtKB Entries (1)

Q4D3W2
PYRD_TRYCC
Trypanosoma cruzi strain CL Brener
Dihydroorotate dehydrogenase (fumarate)

PDB Structure

PDB 3W75
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-4-149
Inaoka, D.K., Iida, M., Tabuchi, T., Lee, N., Hashimoto, S., Matsuoka, S., Kuranaga, T., Shiba, T., Sakamoto, K., Suzuki, S., Balogun, E.O., Nara, T., Aoki, T., Inoue, M., Honma, T., Tanaka, A., Harada, S., Kita, K.
To be Published