CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P00533
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00533
EGFR_HUMAN
Homo sapiens
Epidermal growth factor receptor

PDB Structure

PDB 3W2P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.
Sogabe, S., Kawakita, Y., Igaki, S., Iwata, H., Miki, H., Cary, D.R., Takagi, T., Takagi, S., Ohta, Y., Ishikawa, T.
Acs Med.Chem.Lett.