CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1400
Functional Family Ferrochelatase

Enzyme Information

4.99.1.1
Protoporphyrin ferrochelatase.
based on mapping to UniProt P22830
Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
-!- The enzyme catalyzes the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria.

UniProtKB Entries (1)

P22830
HEMH_HUMAN
Homo sapiens
Ferrochelatase, mitochondrial

PDB Structure

PDB 3W1W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Salicylic Acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity
Gupta, V., Liu, S., Ando, H., Ishii, R., Tateno, S., Kaneko, Y., Yugami, M., Sakamoto, S., Yamaguchi, Y., Nureki, O., Handa, H.
Mol.Pharmacol.