CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 3-oxoacyl-[acyl-carrier protein] reductase

Enzyme Information

1.1.1.36
Acetoacetyl-CoA reductase.
based on mapping to UniProt P14697
(R)-3-hydroxyacyl-CoA + NADP(+) = 3-oxoacyl-CoA + NADPH.

UniProtKB Entries (1)

P14697
PHAB_CUPNH
Cupriavidus necator H16
Acetoacetyl-CoA reductase

PDB Structure

PDB 3VZR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme A (Acetoacetyl-CoA) reductase from Ralstonia eutropha reveals two mutations responsible for enhanced kinetics
Matsumoto, K., Tanaka, Y., Watanabe, T., Motohashi, R., Ikeda, K., Tobitani, K., Yao, M., Tanaka, I., Taguchi, S.
Appl.Environ.Microbiol.