CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.200.40
Functional Family Sphingosine kinase 1

Enzyme Information

2.7.1.91
Sphingosine kinase.
based on mapping to UniProt Q9NYA1
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate.
-!- The enzyme is involved in the production of sphingolipid metabolites. -!- It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine. -!- The exact substrate range depends on the species.
2.3.1.-
Transferring groups other than amino-acyl groups.
based on mapping to UniProt Q9NYA1

UniProtKB Entries (1)

Q9NYA1
SPHK1_HUMAN
Homo sapiens
Sphingosine kinase 1

PDB Structure

PDB 3VZC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.
Wang, Z., Min, X., Xiao, S.H., Johnstone, S., Romanow, W., Meininger, D., Xu, H., Liu, J., Dai, J., An, S., Thibault, S., Walker, N.
Structure