CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28504
HIR2_HIRME
Hirudo medicinalis
Hirudin-2

PDB Structure

PDB 3VXF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Neutron and X-ray crystallographic analysis of the human alpha-thrombin-bivalirudin complex at pD 5.0: protonation states and hydration structure of the enzyme-product complex
Yamada, T., Kurihara, K., Ohnishi, Y., Tamada, T., Tomoyori, K., Masumi, K., Tanaka, I., Kuroki, R., Niimura, N.
Biochim.Biophys.Acta