CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.465.10
Functional Family

Enzyme Information

1.21.3.7
Tetrahydrocannabinolic acid synthase.
based on mapping to UniProt Q8GTB6
Cannabigerolate + O(2) = Delta(9)-tetrahydrocannabinolate + H(2)O(2).
-!- The cofactor is covalently bound. -!- Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. -!- The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta(9)-THCA with lower efficiency. -!- The traditional numbering called Delta(9)-tetrahydrocannabinolate, Delta(1)-tetrahydrocannabinolate. -!- Systematic peripheral numbering is now recommended.

UniProtKB Entries (1)

Q8GTB6
THCAS_CANSA
Cannabis sativa
Tetrahydrocannabinolic acid synthase

PDB Structure

PDB 3VTE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa
Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S., Kuroki, R.
J.Mol.Biol.