CATH Classification
Domain Context
CATH Clusters
| Superfamily | Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 |
| Functional Family | Berberine bridge enzyme-like 15 |
Enzyme Information
| 1.21.3.7 |
Tetrahydrocannabinolic acid synthase.
based on mapping to UniProt Q8GTB6
Cannabigerolate + O(2) = Delta(9)-tetrahydrocannabinolate + H(2)O(2).
-!- The cofactor is covalently bound. -!- Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. -!- The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta(9)-THCA with lower efficiency. -!- The traditional numbering called Delta(9)-tetrahydrocannabinolate, Delta(1)-tetrahydrocannabinolate. -!- Systematic peripheral numbering is now recommended.
|
UniProtKB Entries (1)
| Q8GTB6 |
THCAS_CANSA
Cannabis sativa
Tetrahydrocannabinolic acid synthase
|
PDB Structure
| PDB | 3VTE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa
J.Mol.Biol.
|