CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Renin

Enzyme Information

3.4.23.15
Renin.
based on mapping to UniProt P00797
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

UniProtKB Entries (1)

P00797
RENI_HUMAN
Homo sapiens
Renin

PDB Structure

PDB 3VSX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors
Nakamura, Y., Sugita, C., Meguro, M., Miyazaki, S., Tamaki, K., Takahashi, M., Nagai, Y., Nagayama, T., Kato, M., Suemune, H., Nishi, T.
Bioorg.Med.Chem.Lett.