CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.20
Functional Family

Enzyme Information

6.3.2.43
[Amino group carrier protein]--L-2-aminoadipate ligase.
based on mapping to UniProt Q5SH23
ATP + [amino group carrier protein]-C-terminal-L-glutamate + L-2- aminoadipate = ADP + phosphate + [amino group carrier protein]-C- terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate.
-!- The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW. -!- This reaction is part of the lysine biosynthesis pathway in these organisms. -!- Formerly EC 6.3.2.n4.

UniProtKB Entries (1)

Q5SH23
LYSX_THET8
Thermus thermophilus HB8
Alpha-aminoadipate--LysW ligase LysX

PDB Structure

PDB 3VPD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
Ouchi, T., Tomita, T., Horie, A., Yoshida, A., Takahashi, K., Nishida, H., Lassak, K., Taka, H., Mineki, R., Fujimura, T., Kosono, S., Nishiyama, C., Masui, R., Kuramitsu, S., Albers, S.V., Kuzuyama, T., Nishiyama, M.
Nat.Chem.Biol.