CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

4.1.1.15
Glutamate decarboxylase.
based on mapping to UniProt Q99259
L-glutamate = 4-aminobutanoate + CO(2).
-!- The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.

UniProtKB Entries (1)

Q99259
DCE1_HUMAN
Homo sapiens
Glutamate decarboxylase 1

PDB Structure

PDB 3VP6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates
Langendorf, C.G., Tuck, K.L., Key, T.L.G., Fenalti, G., Pike, R.N., Rosado, C.J., Wong, A.S.M., Buckle, A.M., Law, R.H.P., Whisstock, J.C.
Biosci.Rep.