CATH Domain 3vmqA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.3810	Penicillin binding protein transpeptidase fold
	1.10.3810.10	Biosynthetic peptidoglycan transglycosylase-like

Domain Context

CATH Clusters

Superfamily	Biosynthetic peptidoglycan transglycosylase-like
Functional Family

Enzyme Information

2.4.1.129

Peptidoglycan glycosyltransferase.

based on mapping to UniProt Q99T05

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)- diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys- D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

-!- The enzyme also works when the lysine residue is replaced by meso- 2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-center, as it is in Gram- negative and some Gram-positive organisms. -!- The undecaprenol involved is ditrans,octacis-undecaprenol. -!- Involved in the synthesis of cell-wall peptidoglycan.

UniProtKB Entries (1)

Q99T05

MGT_STAAM

Staphylococcus aureus subsp. aureus Mu50

Monofunctional glycosyltransferase

PDB Structure

PDB	3VMQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism Huang, C.Y., Shih, H.W., Lin, L.Y., Tien, Y.W., Cheng, T.J.R., Cheng, W.C., Wong, C.H., Ma, C. Proc.Natl.Acad.Sci.USA