CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.520.10
Functional Family

Enzyme Information

1.11.1.21
Catalase peroxidase.
based on mapping to UniProt O59651
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

O59651
KATG2_HALMA
Haloarcula marismortui ATCC 43049
Catalase-peroxidase 2

PDB Structure

PDB 3VLH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Catalatic Implication Guided by Structure, Kinetics and Theoretical Studies on Ser305Thr and Arg409Leu Variants of HmKatG
Sato, T., Higuchi, W., Yoshimatsu, K., Fujiwara, T.
To be Published