CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.8.60
Functional Family Spastin

Enzyme Information

5.6.1.1
Microtubule-severing ATPase.
based on mapping to UniProt Q9UBP0
n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
-!- A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome. -!- Formerly EC 3.6.4.3.

UniProtKB Entries (1)

Q9UBP0
SPAST_HUMAN
Homo sapiens
Spastin

PDB Structure

PDB 3VFD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the human spastin AAA domain.
Taylor, J.L., White, S.R., Lauring, B., Kull, F.J.
J.Struct.Biol.