CATH Domain 3v8sA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q13464

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13464

ROCK1_HUMAN

Homo sapiens

Rho-associated protein kinase 1

PDB Structure

PDB	3V8S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-based and structure-guided discovery and optimization of rho kinase inhibitors. Li, R., Martin, M.P., Liu, Y., Wang, B., Patel, R.A., Zhu, J.Y., Sun, N., Pireddu, R., Lawrence, N.J., Li, J., Haura, E.B., Sung, S.S., Guida, W.C., Schonbrunn, E., Sebti, S.M. J.Med.Chem.