CATH Classification

Domain Context

CATH Clusters

Superfamily 3.60.21.10
Functional Family Serine/threonine-protein phosphatase

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt P62136
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

Q12972
PP1R8_HUMAN
Homo sapiens
Nuclear inhibitor of protein phosphatase 1

PDB Structure

PDB 3V4Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme.
O'Connell, N., Nichols, S.R., Heroes, E., Beullens, M., Bollen, M., Peti, W., Page, R.
Structure