CATH Classification

Domain Context

CATH Clusters

Superfamily 2.80.10.50
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P0DPI1
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (2)

P0DPI1
BXA1_CLOBH
Clostridium botulinum A str. Hall
Botulinum neurotoxin type A
Q45914
BXAN_CLOBO
Clostridium botulinum
Non-toxic nonhemagglutinin type A

PDB Structure

PDB 3V0B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Gu, S., Rumpel, S., Zhou, J., Strotmeier, J., Bigalke, H., Perry, K., Shoemaker, C.B., Rummel, A., Jin, R.
Science