CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.520.10
Functional Family Catalase-peroxidase

Enzyme Information

1.11.1.21
Catalase peroxidase.
based on mapping to UniProt A4QUT2
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

A4QUT2
KATG2_MAGO7
Pyricularia oryzae 70-15
Catalase-peroxidase 2

PDB Structure

PDB 3UT2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High Conformational Stability of Secreted Eukaryotic Catalase-peroxidases: ANSWERS FROM FIRST CRYSTAL STRUCTURE AND UNFOLDING STUDIES.
Zamocky, M., Garcia-Fernandez, Q., Gasselhuber, B., Jakopitsch, C., Furtmuller, P.G., Loewen, P.C., Fita, I., Obinger, C., Carpena, X.
J.Biol.Chem.