CATH Classification

Domain Context

CATH Clusters

Functional Family Protein kinase C delta

Enzyme Information
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P28867
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC
Protein kinase C.
based on mapping to UniProt P28867
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC

UniProtKB Entries (1)

Mus musculus
Protein kinase C delta type

PDB Structure

External Links
Primary Citation
Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase C delta
Shanmugasundararaj, S., Das, J., Sandberg, W.S., Zhou, X., Wang, D., Messing, R.O., Bruzik, K.S., Stehle, T., Miller, K.W.