CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08581
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581
MET_HUMAN
Homo sapiens
Hepatocyte growth factor receptor

PDB Structure

PDB 3U6H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.
Norman, M.H., Liu, L., Lee, M., Xi, N., Fellows, I., D'Angelo, N.D., Dominguez, C., Rex, K., Bellon, S.F., Kim, T.S., Dussault, I.
J.Med.Chem.