1 keywords

CATH Domain 3u1yA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.230 Ribosomal Protein S5; domain 2
Homologous Superfamily 3.30.230.20 lpxc deacetylase, domain 1

Domain Context

CATH Clusters

Superfamily lpxc deacetylase, domain 1
Functional Family UDP-3-O-acyl-N-acetylglucosamine deacetylase

Enzyme Information

3.5.1.108
UDP-3-O-acyl-N-acetylglucosamine deacetylase.
based on mapping to UniProt P47205
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- The enzyme catalyzes a committed step in the biosynthesis of lipid A. -!- Formerly EC 3.5.1.n1.

UniProtKB Entries (1)

P47205
LPXC_PSEAE
Pseudomonas aeruginosa PAO1
UDP-3-O-acyl-N-acetylglucosamine deacetylase

PDB Structure

PDB 3U1Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Potent inhibitors of LpxC for the treatment of Gram-negative infections.
Brown, M.F., Reilly, U., Abramite, J.A., Arcari, J.T., Oliver, R., Barham, R.A., Che, Y., Chen, J.M., Collantes, E.M., Chung, S.W., Desbonnet, C., Doty, J., Doroski, M., Engtrakul, J.J., Harris, T.M., Huband, M., Knafels, J.D., Leach, K.L., Liu, S., Marfat, A., Marra, A., McElroy, E., Melnick, M., Menard, C.A., Montgomery, J.I., Mullins, L., Noe, M.C., O'Donnell, J., Penzien, J., Plummer, M.S., Price, L.M., Shanmugasundaram, V., Thoma, C., Uccello, D.P., Warmus, J.S., Wishka, D.G.
J.Med.Chem.