CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q13464
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13464
ROCK1_HUMAN
Homo sapiens
Rho-associated protein kinase 1

PDB Structure

PDB 3TWJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer.
Patel, R.A., Forinash, K.D., Pireddu, R., Sun, Y., Sun, N., Martin, M.P., Schonbrunn, E., Lawrence, N.J., Sebti, S.M.
Cancer Res.