CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Histone acetyltransferase

Enzyme Information

2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt Q08649
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

UniProtKB Entries (1)

Q08649
ESA1_YEAST
Saccharomyces cerevisiae S288C
Histone acetyltransferase ESA1

PDB Structure

PDB 3TO7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
MYST protein acetyltransferase activity requires active site lysine autoacetylation.
Yuan, H., Rossetto, D., Mellert, H., Dang, W., Srinivasan, M., Johnson, J., Hodawadekar, S., Ding, E.C., Speicher, K., Abshiru, N., Perry, R., Wu, J., Yang, C., Zheng, Y.G., Speicher, D.W., Thibault, P., Verreault, A., Johnson, F.B., Berger, S.L., Sternglanz, R., McMahon, S.B., Cote, J., Marmorstein, R.
Embo J.