CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.40.20
Functional Family Transitional endoplasmic reticulum ATPase

Enzyme Information

3.6.4.6
Vesicle-fusing ATPase.
based on mapping to UniProt P55072
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

P55072
TERA_HUMAN
Homo sapiens
Transitional endoplasmic reticulum ATPase

PDB Structure

PDB 3TIW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97.
Hanzelmann, P., Schindelin, H.
J.Biol.Chem.